Barack Obama's top choice for secretary of homeland security is Arizona Gov. Janet Napolitano, multiple sources say
If Napolitano does indeed accept this job, that both removes her from contention for a 2010 Senate race, and also would move up Republican Jan Brewer, Arizona's Secretary of State, into the Governor's mansion. Brewer is already mentioned as a likely candidate for Governor in 2010, so this would obviously give her a big leg up for the entire field.